Xenoestrogens released from lacquer coatings in food cans Brotons, José Antonio Olea Serrano, Fátima Villalobos Torres, Mercedes Pedraza Muriel, Vicente Olea Serrano, Nicolás Bisphenol-A Food containers Lacquer coating Xenoestrogens We present data showing that some foods preserved in lacquer-coated cans and the liquid in them may acquire estrogenic activity. Hormonal activity was measured using the E-screen bioassay. The biological activity of vegetables packed in cans was a result of plastic monomers used in manufacturing the containers. The plastic monomer bisphenol-A, identified by mass spectrometry, was found as a contaminant not only in the liquid of the preserved vegetables but also in water autoclaved in the cans. The amount of bisphenol-A in the extracts accounted for all the hormonal activity measured. Although the presence of other xenoestrogens cannot be ruled out, it is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating. The use of plastic in food-packaging materials may require closer scrutiny to determine whether epoxy resins and polycarbonates contribute to human exposure to xenoestrogens. 2014-07-02T11:38:50Z 2014-07-02T11:38:50Z 1995 info:eu-repo/semantics/article Brotons, J.A.; et al. Xenoestrogens released from lacquer coatings in food cans. Environmental Health Perspectives, 103(6): 608-612 (1995). [http://hdl.handle.net/10481/32437] 0091-6765 http://hdl.handle.net/10481/32437 10.2307/3432439 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License National Institute of Environmental Health