Entry, dispersion and differentiation of microglia in the developing central nervous system Navascués Martínez, Julio Calvente Iglesias, Ruth Marín-Teva, José Luis Cuadros Ojeda, Miguel Ángel Microglia Hematopoietic lineage Meninges Migration Proliferation Microglial cells within the developing central nervous system (CNS) originate from mesodermic precursors of hematopoietic lineage that enter the nervous parenchyma from the meninges, ventricular space and/or blood stream. Once in the nervous parenchyma, microglial cells increase in number and disperse throughout the CNS; these cells finally differentiate to become fully ramified microglial cells. In this article we review present knowledge on these phases of microglial development and the factors that probably influence them. 2014-05-26T07:21:38Z 2014-05-26T07:21:38Z 2000 info:eu-repo/semantics/article Navascués, J.; et al. Entry, dispersion and differentiation of microglia in the developing central nervous system. Anais da Academia Brasileira de Ciencias, 72(1): 91-102 (2000). [http://hdl.handle.net/10481/31911] 0001-3765 1678-2690 http://hdl.handle.net/10481/31911 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Academia Brasileira de Ciências