Brain Structural Correlates of Reward Sensitivity and Impulsivity in Adolescents with Normal and Excess Weight Moreno-López, Laura Soriano-Mas, Carles Delgado-Rico, Elena Schmidt Río Valle, Jacqueline Verdejo García, Antonio Javier Adolescents Central nervous system Magnetic resonance imaging Motivation Neuroimaging Obesity Personality Prefrontal cortex Introduction Neuroscience evidence suggests that adolescent obesity is linked to brain dysfunctions associated with enhanced reward and somatosensory processing and reduced impulse control during food processing. Comparatively less is known about the role of more stable brain structural measures and their link to personality traits and neuropsychological factors on the presentation of adolescent obesity. Here we aimed to investigate regional brain anatomy in adolescents with excess weight vs. lean controls. We also aimed to contrast the associations between brain structure and personality and cognitive measures in both groups. Methods Fifty-two adolescents (16 with normal weight and 36 with excess weight) were scanned using magnetic resonance imaging and completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), the UPPS-P scale, and the Stroop task. Voxel-based morphometry (VBM) was used to assess possible between-group differences in regional gray matter (GM) and to measure the putative differences in the way reward and punishment sensitivity, impulsivity and inhibitory control relate to regional GM volumes, which were analyzed using both region of interest (ROI) and whole brain analyses. The ROIs included areas involved in reward/somatosensory processing (striatum, somatosensory cortices) and motivation/impulse control (hippocampus, prefrontal cortex). Results Excess weight adolescents showed increased GM volume in the right hippocampus. Voxel-wise volumes of the second somatosensory cortex (SII) were correlated with reward sensitivity and positive urgency in lean controls, but this association was missed in excess weight adolescents. Moreover, Stroop performance correlated with dorsolateral prefrontal cortex volumes in controls but not in excess weight adolescents. Conclusion Adolescents with excess weight have structural abnormalities in brain regions associated with somatosensory processing and motivation. 2014-03-18T13:27:24Z 2014-03-18T13:27:24Z 2012 info:eu-repo/semantics/article Moreno-López, L.; et al. Brain Structural Correlates of Reward Sensitivity and Impulsivity in Adolescents with Normal and Excess Weight. Plos One, 7(11): e49185 (2012). [http://hdl.handle.net/10481/30945] 1932-6203 doi: 10.1371/journal.pone.0049185 http://hdl.handle.net/10481/30945 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Public Library of Science (PLOS)