Urinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approach
Metadatos
Mostrar el registro completo del ítemAutor
Kiwitt Cárdenas, Jonathan; Arense Gonzalo, Julián J.; Adoamnei, Evdochia; Sarabia Cos, Laura; Vela Soria, Fernando; Fernández Cabrera, Mariana Fátima; Gosálvez, Jaime; Mendiola, Jaime; Torres-Cantero, Alberto M.Editorial
Elsevier
Materia
Bayesian Kernel Machine Regression Endocrine disruptor compounds Male infertility
Fecha
2024Referencia bibliográfica
Science of the Total Environment 912 (2024) 169314 [10.1016/j.scitotenv.2023.169314]
Patrocinador
Fundación Séneca, Agencia de Ciencia y Tecnología de la Región de Murcia [08808/PI/08, 19443/PI/14]; Consejería de Innovación, Junta de Andalucía [P09-CTS-5488]; Ministerio de Economía, Industria y Competitividad, Instituto de Salud Carlos III (Acción Estratégica en Salud, AES) [PI10/00985, PI13/01237, PI13/ 02406]Resumen
People are daily exposed to multiple endocrine disruptor compounds (EDCs) that may interfere with different
molecular and cellular processes, promoting a potential estrogenic, androgenic, or anti-androgenic state. However,
most epidemiological studies attempting to establish relationships between EDCs exposure and health effects
are still considering individual compounds. A few studies have shown associations between exposure to
individual non-persistent EDCs and sperm DNA fragmentation (SDF) in different male populations. Thus, the aim
of this study was to investigate associations between combined exposure to non-persistent EDCs and SDF index in
young men. A cross-sectional study was conducted with 158 healthy university students from Southeaster Spain.
The participants provided spot urine and semen samples on the same day. The concentrations of urinary
bisphenol A (BPA), benzophenones [2,4-dihydroxybenzophenone (BP-1); 2,2′,4,4′-tetrahydroxybenzophenone
(BP-2), 2-hydroxy-4-methoxybenzophenone (BP-3), 2,2′-dihydroxy-4-methoxybenzophenone (BP-8), 4-hydroxybenzophenone
(4OHBP)], and parabens (methylparaben, ethylparaben, propylparaben, butylparaben) were
measured by dispersive liquid-liquid microextraction and ultrahigh-performance liquid chromatography with
tandem mass spectrometry detection. SDF was analysed using a Sperm Chromatin Dispersion test. Statistical
analyses were carried out using Bayesian Kernel Machine Regression models to evaluate associations between
combined exposure to these compounds and SDF index while adjusting by relevant covariates. The increase in
urinary concentration of 4OHBP was found to be the most important contributor to the negative association
between urinary EDCs concentrations and SDF index, being of -5.5 % [95 % CI: -10.7, -0.3] for those in
percentile 50, and -5.4 % [95 % CI: -10.8, -0.1] for those in percentile 75. No significant associations were
observed between other EDCs and SDF index. Our findings show that urinary 4OHBP levels may be associated
with a decrease in the SDF index. Nonetheless, the effects we observed were likely to be small and of uncertain
clinical significance. Further research is needed to replicate our findings in other male populations.