Gene pathways associated with mitochondrial function, oxidative stress and telomere length are differentially expressed in the liver of rats fed lifelong on virgin olive, sunflower or fish oils
Metadatos
Mostrar el registro completo del ítemAutor
Varela López, Alfonso; Pérez-López, María Patricia; Ramírez Tortosa, César Luis; Battino, Maurizio; Granados Principal, Sergio; Ramírez Tortosa, María del Carmen; Ochoa Herrera, Julio José; Vera Ramírez, Laura; Giampieri, Francesca; Quiles Morales, José LuisEditorial
Elsevier
Materia
Gene expression Mitochondria MUFA
Fecha
2018Referencia bibliográfica
Varela-Lopez A, Pérez-López MP, Ramirez-Tortosa CL, Battino M, Granados-Principal S, Ramirez-Tortosa MDC, Ochoa JJ, Vera-Ramirez L, Giampieri F, Quiles JL. Gene pathways associated with mitochondrial function, oxidative stress and telomere length are differentially expressed in the liver of rats fed lifelong on virgin olive, sunflower or fish oils.J Nutr Biochem. 2018 Feb;52:36-44. doi:10.1016/j.jnutbio.2017.09.007
Patrocinador
Spanish Ministry of Education and Science (AGL2008-01057); Government of Andalusia (AGR832); CEI BioTic Granada (CEI2013-P- 20); Spanish Ministry of EducationResumen
This study investigates the effect of lifelong intake of different fat sources rich in monounsaturated (virgin olive oil), n6 polyunsaturated (sunflower oil) or n3 polyunsaturated (fish oil) fatty acids in the aged liver. Male Wistar rats fed lifelong on diets differing in the fat source were killed at 6 and at 24 months of age. Liver histopathology, mitochondrial ultrastructure, biogenesis, oxidative stress, mitochondrial electron transport chain, relative telomere length and gene expression profiles were studied. Aging led to lipid accumulation in the liver. Virgin olive oil led to the lowest oxidation and ultrastructural alterations. Sunflower oil induced fibrosis, ultrastructural alterations and high oxidation. Fish oil intensified oxidation associated with age, lowered electron transport chain activity and enhanced the relative telomere length. Gene expression changes associated with age in animals fed virgin olive oil and fish oil were related mostly to mitochondrial function and oxidative stress pathways, followed by cell cycle and telomere length control. Sunflower oil avoided gene expression changes related to age. According to the results, virgin olive oil might be considered the dietary fat source that best preserves the liver during the aging process.