The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
Metadatos
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Elsevier
Materia
Pancreatic cancer Pancreatic ductal adenocarcinoma Pancreatic neuroendocrine tumors Intraductal papillary mucinous neoplasms Intraductal papillary mucinous neoplasms Chronic pancreatitis Genetic epidemiology
Fecha
2023-05-08Referencia bibliográfica
D. Campa et al. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. Critical Reviews in Oncology / Hematology 186 (2023) 104020[https://doi.org/10.1016/j.critrevonc.2023.104020]
Patrocinador
Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019—ID. 23672 project—P.I. Campa Daniele and IG 2021 ID – 26201 project P.I; The Czech Ministry of Health, NU21–07–00247 and from Programme EXCELES; ID Project No. LX22NPO5102. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG); Italian Minister of Health, Ricerca Corrente program 2022–2024; Cancer Research UK (C7690/A26881, C18616/A25153) and Pancreatic Cancer UK. Sample accrual at the Amsterdam UMC was supported by the AMC Foundation; COST Action TRANSPAN; CA21116; COST (European Cooperation in Science and Technology)Resumen
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33
susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant
hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease.
Additionally, the inability to adequately power research questions prevents small monocentric studies from being
successful. Several consortia have been established to pursue a better understanding of the genetic architecture of
pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is
spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups
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