Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Metadatos
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MDPI
Materia
Retinoblastoma PRb Oral cancer Prognosis Systematic review Meta-analysis
Fecha
2023-06-09Referencia bibliográfica
López-Ansio, M.; Ramos-García, P.; González-Moles, M.Á. Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers 2023, 15, 3132. [https://doi.org/10.3390/ cancers15123132]
Resumen
This systematic review and meta-analysis aims to evaluate the scientific evidence on the implications
of retinoblastoma protein (pRb) alterations in oral cancer, in order to determine its prognostic
and clinicopathological significance. PubMed, Embase, Web of Science, and Scopus were searched
for studies published before February 2022, with no restrictions by publication date or language. The
quality of the studies using the Quality in Prognosis Studies tool (QUIPS tool). Meta-analysis was
conducted to achieve the proposed objectives, as well as heterogeneity, subgroup, meta-regression,
and small study-effects analyses. Twenty studies that met the inclusion criteria (2451 patients) were
systematically reviewed and meta-analyzed. Our results were significant for the association between
the loss of pRb expression and a better overall survival (HR = 0.79, 95%CI = 0.64–0.98, p = 0.03),
whereas no significant results were found for disease-free survival or clinico-pathological parameters
(T/N status, clinical stage, histological grade). In conclusion, our evidence-based results demonstrate
that loss of pRb function is a factor associated with improved survival in patients with OSCC.
Research lines that should be developed in the future are highlighted