Towards the Development of Novel Diclofenac Multicomponent Pharmaceutical Solids
Metadatos
Mostrar el registro completo del ítemAutor
Acebedo Martínez, Francisco Javier; Alarcón Payer, Carolina; Barrales Ruiz, Helena María; Niclos Gutiérrez, Juan; Domínguez Martín, Alicia; Choquesillo Lazarte, DuaneEditorial
MDPI
Materia
Diclofenac Nucleobases Mechanochemical synthesis Multicomponent materials Pharmaceutical solid forms
Fecha
2022-07-26Referencia bibliográfica
Acebedo-Martínez, F.J... [et al.]. Towards the Development of Novel Diclofenac Multicomponent Pharmaceutical Solids. Crystals 2022, 12, 1038. [https://doi.org/10.3390/cryst12081038]
Patrocinador
Spanish Agencia Estatal de Investigacion of the Ministerio de Ciencia, Innovacion y Universidades (MICIU); European Commission PGC2018-102047-B-I00; FEDER-Universidad de Granada, Spain B-FQM-478-UGR20Resumen
Multicomponent pharmaceutical materials offer new opportunities to address drug physicochemical
issues and to obtain improved drug formulation, especially on oral administration drugs.
This work reports three new multicomponent pharmaceutical crystals of the non-steroidal antiinflammatory
drug diclofenac and the nucleobases adenine, cytosine, and isocytosine. They have
been synthesized by mechanochemical methods and been characterized in-depth in solid-state by
powder and single crystal X-ray diffraction, as well as other techniques such as thermal analyses
and infrared spectroscopy. Stability and solubility tests were also performed on these materials. This
work aimed to evaluate the physicochemical properties of these solid forms, which revealed thermal
stability improvement. Dissociation of the new phases was observed in water, though. This fact is
consistent with the reported observed layered structures and BFDH morphology calculations.