A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer
Metadatos
Mostrar el registro completo del ítemEditorial
MDPI
Materia
Periodontitis Dysbiosis Fusobacterium nucleatum Colorectal cancer
Fecha
2022-04-15Referencia bibliográfica
Mesa, F... [et al.]. A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer. Medicina 2022, 58, 546. [https://doi.org/10.3390/medicina58040546]
Resumen
There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal
cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics
of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide
data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of
the most frequent tumours diagnosed and whose incidence increases every year. We describe, from
its recent origin, the relationship between this bacterium and this type of cancer and the knowledge
and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided
synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the
main questions and further research perspectives are presented.