Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance
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AuthorVarela-López, Alfonso; Navarro-Hortal, María D.; Giampieri, Francesca; Bullón, Pedro; Battino, Maurizio; Quiles Morales, José Luis
Varela-López, A. [et al.]. Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance. Molecules 2018, 23, 1226; doi:10.3390/molecules23051226.
SponsorshipAuthors acknowledge to the University of Granada and the Autonomous Government of Andalusia for partial support of the research team. Francesca Giampieri was supported by a Fondazione Umberto Veronesi Fellowship. Alfonso Varela-López is recipient of a postdoctoral fellowship from the Foundation Alfonso Martin Escudero. María D. Navarro-Hortal has enjoyed a Research Initiation Scholarship for undergraduate students of the University of Granada’s Own Plan during the 2016–2017 academic year and a Student Collaboration Grant for Research in University Departments for the academic year 2017–2018, from the Spanish Ministry of Education, Culture and Sports, 2017/2018 call.
Periodontal disease, a relevant public health problem worldwide, is generally considered a common pathology of elderly people. In this respect, there is agreement about that nutritional status may be a modifying factor in the progression and healing of the periodontal tissues. Vitamins have been recommended as nutraceuticals for prevention and treatment of some pathological conditions, such as cardiovascular diseases, obesity or cancer. Thus, a systematic approach to determining how the different vitamin type could ameliorate periodontal risks or improve periodontal health is necessary to further the understanding of the potential benefits and risks of vitamins supplementation use. For this, a systematic review of English-written literature in PubMed until February 2018, which included both human and animal research on the relationship of each vitamin with periodontal disease, was conducted. Among all the analyzed vitamins those with antioxidant capacity and effects on immune system seem to be useful for prevention or improvement of periodontal disease, as well as those implicated in bone metabolism. In the first case, there are quite information in favor of various vitamins, mainly vitamin C, that is the most studied. In the second case, vitamin D seems to have the most relevant role.