Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
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AuthorParedes, M. Dolores; Romecín, Paola; Atucha, Noemí M.; O'Valle, Francisco; Castillo, Julián; Ortiz, M. Clara; García-Estañ, Joaquín
FlavonoidsNitric oxideNeartKidneySodium balancePhenylephrineAcetylcholine
Paredes, M. D. [et al.]. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients 2018, 10, 484.
SponsorshipThis report was supported by a grant from the National Spanish R&D Program CENIT of the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific features for the elderly”, CEN-20091006; Acronym: SENIFOOD.We have not received funds for covering the costs to publish in open access. We acknowledge the assistance of Justin Davis with the English language.
Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.