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dc.contributor.authorAl Fazazi, Saad
dc.contributor.authorCasuso, Rafael A.
dc.contributor.authorAragón Vela, Jerónimo
dc.contributor.authorCasals Vázquez, Cristina
dc.contributor.authorRodríguez Huertas, Jesús Francisco 
dc.date.accessioned2018-11-08T09:32:07Z
dc.date.available2018-11-08T09:32:07Z
dc.date.issued2018-04-27
dc.identifier.citationAl Fazazi et al. Effects of hydroxytyrosol dose on the redox status of exercised rats: the role of hydroxytyrosol in exercise performance. Journal of the International Society of Sports Nutrition (2018) 15:20 [ http://hdl.handle.net/10481/53635]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/53635
dc.description.abstractBackground: Hydroxytyrosol (HT) is a polyphenol found in olive oil that is known for its antioxidant effects. Here, we aimed to describe the effects of a low and high HT dose on the physical running capacity and redox state in both sedentary and exercised rats. Methods: Male Wistar rats were allocated into 6 groups: sedentary (SED; n = 10); SED consuming 20 mg/kg/d HT (SED20; n = 7); SED consuming 300 mg/kg/d HT (SED300; n = 7); exercised (EXE; n = 10); EXE consuming 20 mg/kg/d HT (EXE20; n = 10) and EXE consuming 300 mg/kg/d HT (EXE300; n = 10). All the interventions lasted 10 weeks; the maximal running velocity was assessed throughout the study, whereas daily physical work was monitored during each training session. At the end of the study, the rats were sacrificed by bleeding. Hemoglobin (HGB) and hematocrit (HCT) were measured in the terminal blood sample. Moreover, plasma hydroperoxide (HPx) concentrations were quantified as markers of lipid peroxidation. Results: In sedentary rats, HT induced an antioxidant effect in a dose-dependent manner without implications on running performance. However, if combined with exercise, the 300 mg/kg/d HT dosage exhibited a pro-oxidant effect in the EXE300 group compared with the EXE and EXE20 groups. The EXE20 rats showed a reduction in daily physical work and a lower maximal velocity than the EXE and EXE300 rats. The higher physical capacity exhibited by the EXE300 group was achieved despite the EXE300 rats expressing lower HGB levels and a lower HCT than the EXE20 rats. Conclusions: Our results suggest that a high HT dose induces a systemic pro-oxidant effect and may prevent the loss of performance that was observed with the low HT dose.es_ES
dc.description.sponsorshipThis study was supported by the grant #3650 managed by Fundación General Empresa-Universidad de Granada, and by the investigation group CTS-454 “Impacto fisiológico del estrés oxidativo, deporte, actividad física y salud”es_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectPolyphenolses_ES
dc.subjectROSes_ES
dc.subjectExercise es_ES
dc.subjectHemoglobines_ES
dc.subjectOxidative stress es_ES
dc.subjectAntioxidants es_ES
dc.titleEffects of hydroxytyrosol dose on the redox status of exercised rats: the role of hydroxytyrosol in exercise performancees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1186/s12970-018-0221-3


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España