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dc.contributor.authorPabis, Anna
dc.contributor.authorRisso, Valeria Alejandra
dc.contributor.authorSánchez Ruiz, José Manuel 
dc.contributor.authorKamerlin, Shina CL
dc.date.accessioned2018-07-11T08:14:23Z
dc.date.available2018-07-11T08:14:23Z
dc.date.issued2017-11-12
dc.identifier.citationPabis, Anna; et. al. Cooperativity and flexibility in enzyme evolution. Current Opinion in Structural Biology 2018, 48:83–92 [http://hdl.handle.net/10481/52221]es_ES
dc.identifier.issn0959-440X
dc.identifier.urihttp://hdl.handle.net/10481/52221
dc.description.abstractEnzymes are flexible catalysts, and there has been substantial discussion about the extent to which this flexibility contributes to their catalytic efficiency. What has been significantly less discussed is the extent to which this flexibility contributes to their evolvability. Despite this, recent years have seen an increasing number of both experimental and computational studies that demonstrate that cooperativity and flexibility play significant roles in enzyme innovation. This review covers key developments in the field that emphasize the importance of enzyme dynamics not just to the evolution of new enzyme function(s), but also as a property that can be harnessed in the design of new artificial enzymes.es_ES
dc.description.sponsorshipThe European Research Council has provided financial support under the European Community’s Seventh Framework Program (FP7/2007-2013)/ERC Grant Agreement No. 306474. This work was also funded by the Feder Funds, Grants from the Spanish Ministry of Economy and Competitiveness (BIO2015-66426-R and CSD2009-00088) and the Human Frontier Science Program (RGP0041/2017). A.P. is a Wenner-Gren Foundations Postdoctoral Fellow and S. C. L. K. is a Wallenberg Academy Fellow.es_ES
dc.language.isoenges_ES
dc.publisherElsevier B. V.es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/306474es_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleCooperativity and flexibility in enzyme evolutiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/j.sbi.2017.10.020


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España