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Improved reactive nanoparticles to treat dentin hypersensitivity.
dc.contributor.author | Toledano Osorio, Manuel | |
dc.contributor.author | Osorio Ruiz, María Estrella | |
dc.contributor.author | Sánchez Aguilera, Fátima | |
dc.contributor.author | Medina Castillo, Antonio Luis | |
dc.contributor.author | Osorio Ruiz, Raquel | |
dc.contributor.author | Toledano Pérez, Manuel | |
dc.date.accessioned | 2018-04-20T08:38:01Z | |
dc.date.available | 2018-04-20T08:38:01Z | |
dc.date.issued | 2018-03 | |
dc.identifier.citation | Toledano-Osorio M, Osorio E, Aguilera FS, Luis Medina-Castillo A, Toledano M, Osorio R. Improved reactive nanoparticles to treat dentin hypersensitivity. Acta Biomater. 2018 Mar 24. pii: S1742-7061(18)30164-8 [ http://hdl.handle.net/10481/50334] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/50334 | |
dc.description.abstract | The aim of this study was to evaluate the effectiveness of different nanoparticles-based solutions for dentin permeability reduction and to determine the viscoelastic performance of cervical dentin after their application. Four experimental nanoparticle solutions based on zinc, calcium or doxycycline-loaded polymeric nanoparticles (NPs) were applied on citric acid etched dentin, to facilitate the occlusion and the reduction of the fluid flow at the dentinal tubules. After 24 h and 7 d of storage, cervical dentin was evaluated for fluid filtration. Field emission scanning electron microscopy, energy dispersive analysis, AFM and Nano-DMA analysis were also performed. Complex, storage, loss modulus and tan delta (δ) were assessed. Doxycycline-loaded NPs impaired tubule occlusion and fluid flow reduction trough dentin. Tubules were 100% occluded in dentin treated with calcium-loaded NPs or zinc-loaded NPs, analyzed at 7 d. Dentin treated with both zinc-NPs and calcium-NPs attained the highest reduction of dentinal fluid flow. Moreover, when treating dentin with zinc-NPs, complex modulus values attained at intertubular and peritubular dentin were higher than those obtained after applying calcium-NPs. Zinc-NPs are then supposed to fasten active dentin remodeling, with increased maturity and high mechanical properties. Zinc-based nanoparticles are then proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanoparticles is encouraged. | es_ES |
dc.description.sponsorship | This work was supported by the Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER) [Project MAT2017-85999-P] | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | cervical dentin | es_ES |
dc.subject | hypersensitivity | es_ES |
dc.subject | DMA | es_ES |
dc.subject | nanoparticles | es_ES |
dc.title | Improved reactive nanoparticles to treat dentin hypersensitivity. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1016/j.actbio.2018.03.033. |