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dc.contributor.authorBerglund, Staffan K.es_ES
dc.contributor.authorGarcía-Valdés, Luzes_ES
dc.contributor.authorTorres-Espínola, Francisco J.es_ES
dc.contributor.authorSegura, María Teresaes_ES
dc.contributor.authorMartínez-Zaldivar Moreno, Cristinaes_ES
dc.contributor.authorAguilar Cordero, María Josées_ES
dc.contributor.authorAgil Abdalla, Mhmad Ahmad es_ES
dc.contributor.authorLorente Acosta, José Antonio es_ES
dc.contributor.authorFlorido Navio, Jesús es_ES
dc.contributor.authorPadilla Vinuesa, María del Carmenes_ES
dc.contributor.authorAltmae, Signe es_ES
dc.contributor.authorMarcos, Ascensiónes_ES
dc.contributor.authorLópez-Sabater, María del Carmenes_ES
dc.contributor.authorCampoy Folgoso, Cristina es_ES
dc.date.accessioned2018-03-13T08:38:09Z
dc.date.available2018-03-13T08:38:09Z
dc.date.issued2016
dc.identifier.citationBerglund, S. K.; et al. Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE). BMC Public Health, 16: 207 (2016). [http://hdl.handle.net/10481/49956]es_ES
dc.identifier.issn1471-2458
dc.identifier.urihttp://hdl.handle.net/10481/49956
dc.description.abstractBackground: Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted. Methods: In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks (n = 269), 34 weeks (n = 310) and at delivery (n = 310) and the perinatal characteristics including cord blood biomarkers. Results: Obese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight, waist circumference, and placental weight were higher in the obese group, including a significantly increased prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher levels of folate. The latter was seen also in cord blood. Conclusions: We identified several metabolic alterations in overweight, obese and GD mothers compared to controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in future research regarding the programming of health and disease in children. Trial registration: The trial was registered at clinicaltrials.gov, identifier (NCT01634464).en_EN
dc.description.sponsorshipThis study was granted by Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341); Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01); Research post-doctoral fellowship from the Alfonso Martín Escudero Foundation; MyNewGut FP7 EU Project (Grant agreement n° 613979); DynaHEALTH EU Project HORIZON 2020 (Grant agreement n°: 633595-2); Marie Curie post-doctoral fellowship (FP7, no. 329812, NutriOmics); The first author received Post Doc scholarships from Henning and Johan Throne-Holst’s foundation, and the Swedish Research Council for Health, Working life and Welfare (FORTE, ref 2014–2648).en_EN
dc.language.isoenges_ES
dc.publisherBiomed Centrales_ES
dc.relationMyNewGut FP7 EU Project, nº 613979en_EN
dc.relationMarie Curie post-doctoral fellowship, nº 329812, NutriOmicsen_EN
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectPregnancy en_EN
dc.subjectMaternal overweighten_EN
dc.subjectMaternal obesityen_EN
dc.subjectGestational diabetesen_EN
dc.subjectOffspringen_EN
dc.subjectFetal nutritionen_EN
dc.subjectEarly programmingen_EN
dc.subjectVitamin B12 en_EN
dc.subjectFolateen_EN
dc.subjectIron statusen_EN
dc.subjectGlucose metabolismen_EN
dc.titleMaternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)en_EN
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1186/s12889-016-2809-3


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