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dc.contributor.authorLópez-Mejías, Raqueles_ES
dc.contributor.authorCarmona López, Francisco David es_ES
dc.contributor.authorCastañeda, Santoses_ES
dc.contributor.authorGenre, Fernandaes_ES
dc.contributor.authorRemuzgo-Martínez, Saraes_ES
dc.contributor.authorSevilla-Pérez, Belénes_ES
dc.contributor.authorOrtego-Centeno, Norbertoes_ES
dc.contributor.authorLlorca, Javieres_ES
dc.contributor.authorUbilla, Begoñaes_ES
dc.contributor.authorMijares, Verónicaes_ES
dc.contributor.authorPina, Trinitarioes_ES
dc.contributor.authorMiranda-Filloy, José A.es_ES
dc.contributor.authorNavas Parejo, Antonioes_ES
dc.contributor.authorArgila, Diego dees_ES
dc.contributor.authorAragües, Maximilianoes_ES
dc.contributor.authorRubio, Estebanes_ES
dc.contributor.authorLeón Luque, Manueles_ES
dc.contributor.authorBlanco-Madrigal, Juan Maríaes_ES
dc.contributor.authorGalíndez-Aguirregoikoa, Evaes_ES
dc.contributor.authorJayne, Davides_ES
dc.contributor.authorBlanco, Ricardoes_ES
dc.contributor.authorMartín, Javieres_ES
dc.contributor.authorGonzález-Gay, Miguel A.es_ES
dc.date.accessioned2018-02-15T10:35:58Z
dc.date.available2018-02-15T10:35:58Z
dc.date.issued2017-07-11
dc.identifier.citationLópez-Mejías, R.; et al. A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis. Scientific Reports, 7: 5088 (2017). [http://hdl.handle.net/10481/49560]es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10481/49560
dc.description.abstractThe genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR = 0.56, 95% CI = 0.46–0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P = 6.67E-05, P = 1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease.en_EN
dc.description.sponsorshipThis study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI12/00193) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). RL-M was supported by the Miguel Servet I programme of the Spanish Ministry of Economy and Competitiveness through the grant CP16/00033. FDC was supported by the Ramón y Cajal programme of the Spanish Ministry of Economy and Competitiveness through the grant RYC-2014-16458. FG was recipient of a Sara Borrell postdoctoral fellowship from the “Instituto Carlos III de Salud” at the Spanish Ministry of Health (Spain) (CD15/00095). SR-M and BU were supported by funds from the RETICS Program (RIER) (RD16/0012/0009 and RD12/0009/0013, respectively).en_EN
dc.language.isoengen_EN
dc.publisherNaturees_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licenseen_EN
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_EN
dc.subjectVasculitisen_EN
dc.subjectGenome-wide association study (GWAS)en_EN
dc.subjectHuman leukocyte antigen (HLA)en_EN
dc.subjectHenoch-Schonlein purpuraen_EN
dc.titleA genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitisen_EN
dc.typeinfo:eu-repo/semantics/articleen_EN
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_EN
dc.identifier.doi10.1038/s41598-017-03915-2


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