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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/49156

Title: Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties
Authors: Reyes-Ortega, Felisa
Delgado, Ángel V.
Schneider, Elena K.
Checa Fernández, B. L.
Iglesias, Guillermo R.
Issue Date: 22-Dec-2017
Abstract: Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNPs are investigated. The magnetite/polymer composition of these systems is detected by Fourier Transform Infrared Spectroscopy (FTIR) and quantified by thermogravimetric analysis. The therapeutic possibilities of the designed nanostructures as effective heating agents for magnetic hyperthermia are demonstrated, and specific absorption rates as high as 150 W/g, with 20 mT magnetic field and 205 kHz frequency, are obtained. This magnetic heating response could provide a promising nanoparticle system for combined diagnostics and cancer therapy.
Sponsorship: This research work is supported by Junta de Andalucía (PE2012-FQM694); MINECO (FIS2013-47666-C3-1R), Feder Funds UE; and MINECO Ramón y Cajal programme (RYC-2014-16901).
Publisher: MDPI
Keywords: Hyperthermia
Magnetite nanostructures
Polymer coating
Temperature-responsive polymer
URI: http://hdl.handle.net/10481/49156
ISSN: 2073-4360
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Reyes-Ortega, F.; et al. Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties. Polymers, 10(1): 10 (2017). [http://hdl.handle.net/10481/49156]
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