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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/49154

Title: Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts
Authors: Gasparrini, Massimiliano
Forbes-Hernández, Tamara Y.
Giampieri, Francesca
Afrin, Sadia
Mezzetti, Bruno
Quiles Morales, José Luis
Bompadre, Stefano
Battino, Maurizio
Issue Date: 30-Dec-2016
Abstract: A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells.
Publisher: MDPI
Keywords: Strawberry
LPS
Oxidative stress
Inflammation
Prevention
URI: http://hdl.handle.net/10481/49154
ISSN: 1420-3049
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Gasparrini. M; et al. Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules, 22(1): 164 (2017). [http://hdl.handle.net/10481/49154]
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