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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/49119

Title: Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases
Authors: Plaza-Díaz, Julio
Ruiz-Ojeda, Francisco Javier
Gil-Campos, Mercedes
Gil Hernández, Ángel
Issue Date: 5-Jan-2018
Abstract: The pediatric population is continually at risk of developing infectious and inflammatory diseases. The treatment for infections, particularly gastrointestinal conditions, focuses on oral or intravenous rehydration, nutritional support and, in certain case, antibiotics. Over the past decade, the probiotics and synbiotics administration for the prevention and treatment of different acute and chronic infectious diseases has dramatically increased. Probiotic microorganisms are primarily used as treatments because they can stimulate changes in the intestinal microbial ecosystem and improve the immunological status of the host. The beneficial impact of probiotics is mediated by different mechanisms. These mechanisms include the probiotics’ capacity to increase the intestinal barrier function, to prevent bacterial transferation and to modulate inflammation through immune receptor cascade signaling, as well as their ability to regulate the expression of selected host intestinal genes. Nevertheless, with respect to pediatric intestinal diseases, information pertaining to these key mechanisms of action is scarce, particularly for immune-mediated mechanisms of action. In the present work, we review the biochemical and molecular mechanisms of action of probiotics and synbiotics that affect the immune system.
Sponsorship: Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda and Angel Gil are part of University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES).
Publisher: MDPI
Keywords: Probiotics
Pediatric gastrointestinal infection
Mechanism of action
Intestinal microbiota
Immune system
URI: http://hdl.handle.net/10481/49119
ISSN: 2072-6643
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Plaza-Díaz, J.; et al. Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases. Nutrients, 10(1): 42 (2018). [http://hdl.handle.net/10481/49119]
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