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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/49079

Title: Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells
Authors: Forbes-Hernández, Tamara Y.
Gasparrini, Massimiliano
Afrin, Sadia
Cianciosi, Danila
González-Paramás, Ana M.
Santos-Buelga, Celestino
Mezzetti, Bruno
Quiles Morales, José Luis
Battino, Maurizio
Giampieri, Francesca
Bompadre, Stefano
Issue Date: 28-May-2017
Abstract: Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction.
Publisher: MDPI
Keywords: Strawberry
Anthocyanins
Hypocholesterolemic
Intracellular reactive oxygen species diminution
Antioxidant
URI: http://hdl.handle.net/10481/49079
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Forbes-Hernández, T.Y.; et al. Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. International Journal of Molecular Sciences, 18: 1149 (2017). [http://hdl.handle.net/10481/49079]
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