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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/48481

Title: Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain
Authors: Meer, Thomas P. van der
Artacho-Cordón, Francisco
Swaab, Dick F.
Struik, Dicky
Makris, Konstantinos C.
Wolffenbuttel, Bruce H.R.
Frederiksen, Hanne
Vliet-Ostaptchouk, Jana V. van
Issue Date: 13-Sep-2017
Abstract: Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m2, respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood–brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.
Sponsorship: Jana V. van Vliet-Ostaptchouk is supported by a Diabetes Funds Junior Fellowship from the Dutch Diabetes Research Foundation (project no. 2013.81.1673). This work was supported by the National Consortium for Healthy Ageing (NCHA) (NCHA NGI Grant 050-060-810), and the European Union’s Seventh Framework program (FP7/2007-2013) through the BioSHaRE-EU (Biobank Standardization and Harmonization for Research Excellence in the European Union) project, grant agreement 261433, and by the Danish Center on Endocrine Disrupters and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC).
Publisher: MDPI
Keywords: Bisphenol-A
URI: http://hdl.handle.net/10481/48481
ISSN: 1660-4601
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Meer, T.P.; et al. Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain. International Journal of Environmental Research and Public Health, 14(9): 1059 (2017). [http://hdl.handle.net/10481/48481]
Appears in Collections:OpenAIRE (Open Access Infrastructure for Research in Europe)
DRMF - Artículos

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