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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/47292

Title: AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors
Authors: Casado Ruiz, Jorge
Iñigo-Chaves, Almudena
Jiménez-Ruiz, Sergio
Ríos-Arrabal, Sandra
Carazo Gallego, Ángel
González Puga, María Cristina
Núñez, María Isabel
Ruiz Extremera, Ángeles
Salmerón Escobar, Javier
León López, Josefa
Issue Date: 11-Jun-2017
Abstract: The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could be related to its ability to kill CSCs. Although there are no data linking the loss of p53 function and melatonin synthesis or signaling in cancer, melatonin does activate the p53 tumor-suppressor pathway in this disease. In this work, we analyze whether the expression of melatonin synthesis and signaling genes are related to the expression of CSC markers and the implication of p53 status in samples from patients with CRC. Arylalkylamine N-acetyltransferase (AA-NAT), MT1, and MT2 expression decreased in tumor samples versus normal mucosa samples in mutated p53 (mtp53) tumors versus those with wild-type p53 (wtp53). Further, AA-NAT and MT2 expression were lower in advanced stages of the disease in wtp53 tumors. On the contrary, CD44 and CD66c expression was higher in tumor versus normal mucosa in wtp53 tumors. Additionally, CD44 expression was higher in advanced stages of the disease regardless of the p53 status. Patients with CD44highCD66chigh and wtp53 tumors in advanced stages showed low expression of AA-NAT and MT2 in wtp53 tumors. These results could indicate a possible interaction of these pathways in CRC.
Sponsorship: This research was supported by grants from the Consejería de Salud de la Junta de Andalucía (PI-0677-2013). Josefa León acknowledges sponsorship from the Servicio Andaluz de Salud “Nicolás Monardes” program.
Publisher: MDPI
Keywords: Colorectal cancer
Melatonin
Cancer stem cells
p53
Metastasis
URI: http://hdl.handle.net/10481/47292
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Casado Ruiz, J.; et al. AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. International Journal of Molecular Sciences, 18(6): 1251 (2017). [http://hdl.handle.net/10481/47292]
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