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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/47233

Title: Mitochondrial ferritin deficiency reduces male fertility in mice
Authors: Maccarinelli, Federica
Regoni, Maria
Carmona Rodríguez-Acosta, Fernando
Poli, Maura
Meyron-Holtz, Esther G.
Arosio, Paolo
Issue Date: 9-Jan-2017
Abstract: Mitochondrial ferritin (FtMt) is a functional ferritin targeted to mitochondria that is highly expressed in the testis. To investigate the role of FtMt in the testis we set up a series of controlled matings between FtMt gene-deletion mice (FtMt–/–) with FtMt+/+ mice. We found that the number of newborns per litter and the fertility rate were strongly reduced for the FtMt–/– males, but not for the females, indicating that FtMt has an important role for male fertility. The morphology of the testis and of the spermatozoa of FtMt–/– mice was normal and we did not detect alterations in sperm parameters or in oxidative stress indices. In contrast, we observed that the cauda epididymides of FtMt–/– mice were significantly lighter and contained a lower number of spermatozoa compared with the controls. Also, the ATP content of FtMt–/– spermatozoa was found to be lower than that of FtMt+/+ spermatozoa. These data show that FtMt contributes to sperm epididymis maturation and to male fertility.
Sponsorship: The work was partially supported by MIUR grant PRIN10–11 to P. A. and by Telethon grant GGP1099 to P. A.
Publisher: CSIRO Publishing
Keywords: ATP
Spermatogenesis
Ferritin
Mitochondrial ferritin
Sperm motility
URI: http://hdl.handle.net/10481/47233
ISSN: 1031-3613
1448-5990
Citation: Maccarinelli, F.; et al. Mitochondrial ferritin deficiency reduces male fertility in mice. Reproduction, Fertility and Development: online (2017). [http://hdl.handle.net/10481/47233]
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