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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/47222

Title: Ferritin iron uptake and release in the presence of metals and metalloproteins: Chemical implications in the brain
Authors: Carmona Rodríguez-Acosta, Fernando
Palacios, Óscar
Gálvez Rodríguez, Natividad
Cuesta Martos, Rafael
Atrian, Silvia
Capdevila, Mercè
Domínguez Vera, José Manuel
Issue Date: 2013
Abstract: Living organisms have developed a chemical machinery based on the ferritin protein for the storage, under a nontoxic form, of the iron that is not required for immediate metabolic purposes. Whereas free iron causes extensive cell damage, ferritin iron is not toxic, yet still available for cell requirements. However, iron storage in ferritin is increasingly being recognized as a crucial process related with some neurodegenerative disorders and therefore, an understanding of the management of iron in the brain, especially the processes of iron uptake and release in ferritin, is compulsory to clarify the role of this metalloprotein in these neuropathologies. Although knowledge of iron storage and iron release in ferritin is nowadays still limited, even less information is currently available about the influence of free metal ions and other brain metalloproteins in these processes. In this sense, this review is an excellent opportunity to collect all the information today available about the influence of metals and metalloproteins in ferritin loading and unloading events, which until now are dispersed in the literature. Furthermore, we will focus on the importance of all the above-mentioned interactions in the brain, since the importance of the correct and safe balance of metals in the brain after their well-known implication in neurodegenerative processes such as the Alzheimer's (AD), Parkinson (PD) and prion protein (PPD) diseases is obvious. In this work, we will not only recall the importance and role of ferritin in the brain but also the putative influence of the interaction between ferritin and some metals and/or metalloproteins and other biomolecules on these neurological dysfunctions. The final part of the review will be devoted to draw some guidelines to where the future prospects point to on the basis of the existing information.
Sponsorship: This work was supported by the “Spanish Ministerio de Ciencia e Innovación,” MICINN and FEDER (grants BIO2012-39682-C02-01 and BIO2012-39682-C02-02 respectively to S.A. and M.C., and CTQ2012-32236 to J.M.D.-V.). Authors from Barcelona Universities are members of the 2009SGR-1457 “Grup de Recerca de la Generalitat de Catalunya.” Authors from the Universidad de Granada and Jaen are members of the FQM-368 “Grupo de Investigacion de la Junta de Andalucia.”
Publisher: Elsevier
Keywords: Iron metabolism
Ferritin
Neurochemistry
URI: http://hdl.handle.net/10481/47222
ISSN: 0010-8545
Citation: Carmona Rodríguez-Acosta, F.; et al. Ferritin iron uptake and release in the presence of metals and metalloproteins: Chemical implications in the brain. Coordination Chemistry Reviews, 257(19/20): 2752-2764 (2013). [http://hdl.handle.net/10481/47222]
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