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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/45932

Title: Isoflavonoids from the rhizomes of Iris hungarica and antibacterial activity of the dry rhizomes extract
Other Titles: Isoflavonoides de los rizomas de Iris hungarica y actividad antibacteriana del extracto de rizomas seco
Authors: Mykhailenko, Olga
Kovalyov, Volodumur
Kovalyov, Sergiy
Krechun, Anastasiia
Issue Date: Apr-2017
Abstract: Aim: The aim of the work was isolation and identification of the phenolic compounds from the rhizomes of Iris hungarica. Materials and methods: To establish by chemical and spectral methods for the structures of phenolic compounds, which were isolated from the rhizomes of Iris hungarica Waldst. et Kit. (Iridaceae family). Compounds were obtained by column chromatography on silica gel and their structures were determined by UV, IR, MS, 1H-NMR spectra methods. Preliminary screening of antibacterial activity was determined. Results: From the ethanolic extract of the rhizomes of I. hungarica, which is widespread in Ukraine, for the first time two new for this species isoflavones, teсtorigenin and tectoridin and xanthone mangiferin, together with known isoflavonoids daidzein, genistein, formononetin were isolated. The dry extract of the rhizomes of I. hungarica at a concentration of 1% has shown the highest inhibitory activity for Gram-positive bacteria and fungi.
Objetivo: El objetivo del trabajo es el aislamiento y la identificación de los compuestos fenólicos de los rizomas de Iris hungarica. Materiales y métodos: Se utilizaron métodos químicos y espectrales para conocer las estructuras de compuestos fenólicos que se aislaron de los rizomas de Iris hungarica Waldst. et Kit. (Familia de Iridaceae). Los compuestos se obtuvieron mediante cromatografía en columna sobre gel de sílice y se determinaron sus estructuras mediante análisis de sus espectros por UV, IR, MS, 1H-RMN. Se determinó el cribado preliminar de la actividad antibacteriana. Resultados: Se aislaron por primera vez de los rizomas de Iris hungarica (común en Ucrania) dos isoflavonas, teсtorigenina y tectoridina (nuevas para esta especie), el xantonoide mangiferina y los isoflavonoides daidzeina, genisteina y formononetina. El extracto seco de los rizomas de I. hungarica a una concentración de 1% ha mostrado la actividad inhibitoria más alta para bacterias y hongos Gram-positivos.
Publisher: Universidad de Granada. Facultad de Farmacia
Description: The authors would like gratitude to acting as a Head of the Laboratory of Biochemistry of Microorganisms and Nutrient Media of the State Institution “Institute of Microbiology and Immunology named after I.I. Mechnikov of the National Academy of Medical Sciences of Ukraine,” Cand. Med. Sci. T.P. Osolodchenko for the preliminary screening of antimicrobial activities and a Head of Department of the Ornamental plants, Senior Researcher of the National Botanical Garden n.a. M.M. Gryshko of NAS of Ukraine (Kyiv), Cand. Biol. Sci. Yu.V. Buidin for help in systematical classification of plants.
Keywords: Isoflavonoids
Teсtorigenin
Tectoridin
Mangiferin
Iris hungarica
Antibacterial activity
Isoflavonoides
Teсtorigenina
Tectoridina
Mangiferina
Iris hungarica
Actividad antibacteriana
URI: http://hdl.handle.net/10481/45932
ISSN: 2340-9894
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Mykhailenko, O.; et al. Isoflavonoids from the rhizomes of Iris hungarica and antibacterial activity of the dry rhizomes extract. Ars Pharm, 58(1): 39-45 (2017). [http://hdl.handle.net/10481/45932]
Appears in Collections:APh. vol. 58(1)

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