Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds
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AutorBarrero, Alejandro; Herrador del Pino, María del mar; Arteaga Burón, Pilar; Arteaga, Jesús F.; Arteaga, Alejandro F.
Barrero, A., [et al]. Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds. Molecules 2012, 17, 1448-1467. [http://hdl.handle.net/10481/45345]
Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.