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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/45013

Title: Food Derived Bioactive Peptides and Intestinal Barrier Function
Authors: Martínez-Augustín, Olga
Rivero-Gutiérrez, Belén
Mascaraque Molina, Cristina
Sánchez de Medina, Fermín
Issue Date: 2014
Abstract: A wide range of food-derived bioactive peptides have been shown to exert health-promoting actions and are therefore considered functional foods or nutraceuticals. Some of these actions are related to the maintenance, reinforcement or repairment of the intestinal barrier function (IBF) whose role is to selectively allow the absorption of water, nutrients and ions while preventing the influx of microorganisms from the intestinal lumen. Alterations in the IBF have been related to many disorders, such as inflammatory bowel disease or metabolic syndrome. Components of IBF are the intestinal epithelium, the mucus layer, secretory immunoglobulin A and cells of the innate and adaptive immune systems. Here we review the effects of food derived bioactive peptides on these IBF components. In vitro and in vivo effects, both in healthy and disease states, have been reviewed. Although limited, the available information indicates a potential for food-derived peptides to modify IBF and to contribute to disease treatment, but further research is needed to better isolate responsible peptides, and to help define their mode of action.
Publisher: MDPI
Keywords: Bioactive peptides
Food proteins
functional foods
Nutraceuticals
Intestinal barrier function
Mucus
Immunoglobin A (IgA)
Innate immune response
Inflammation
URI: http://hdl.handle.net/10481/45013
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Martínez-Agustín, O. [et al]. Food Derived Bioactive Peptides and Intestinal Barrier Function. Int. J. Mol. Sci. 2014, 15, 22857-22873. [http://hdl.handle.net/10481/45013]
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