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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/45010

Title: Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases
Authors: Varela-López, Alfonso
Bullón, Pedro
Giampieri, Francesca
Quiles, José L.
Issue Date: 2015
Abstract: One of the main factors able to explain the pathophysiological mechanism of inflammatory conditions that occur in periodontal disease is oxidative stress. Given the emerging understanding of this relationship, host-modulatory therapies using antioxidants could be interesting to prevent or slow the breakdown of soft and hard periodontal tissues. In this context, non-nutrient phenolic compounds of various foods and plants have received considerable attention in the last decade. Here, studies focusing on the relationship between different compounds of this type with periodontal disease have been collected. Among them, thymoquinone, coenzyme Q (CoQ), mangiferin, resveratrol, verbascoside and some flavonoids have shown to prevent or ameliorate periodontal tissues damage in animal models. However evidence regarding this effect in humans is poor and only limited to topical treatments with CoQ and catechins. Along with animal experiments, in vitro studies indicate that possible mechanisms by which these compounds might exert their protective effects include antioxidative properties, oxygen and nitrogen scavenging abilities, and also inhibitory effects on cell signaling cascades related to inflammatory processes which have an effect on RNS or ROS production as well as on antioxidant defense systems.
Publisher: MDPI
Keywords: Anti-inflammatories
Phytochemical
Periodontitis
Polyphenols
URI: http://hdl.handle.net/10481/45010
ISSN: 2076-3921
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Varela-López, A. [et al]. Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases. Antioxidants 2015, 4, 447-481. [http://hdl.handle.net/10481/45010]
Appears in Collections:DFisiología - Artículos

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