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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/44991

Title: Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System
Authors: Montañez-Heredia, Elvira
Irízar, Sofía
Huertas, Pedro J.
Otero, Esperanza
Valle, Marta
Prat, Isidro
Díaz-Galardo, Macarena S.
Perán Quesada, Macarena
Marchal Corrales, Juan Antonio
Issue Date: 2016
Abstract: Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga’s Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades.
Publisher: MDPI
Keywords: Platelet-rich
Knee osteoarthritis
Clinical trial
Hyaluronic acid
URI: http://hdl.handle.net/10481/44991
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Montañez-Heredia, E. [et al]. Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System. Int. J. Mol. Sci. 2016, 17, 1064. [http://hdl.handle.net/10481/44991]
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