Mostrar el registro sencillo del ítem

dc.contributor.authorManzano, Manueles_ES
dc.contributor.authorGirón González, María Dolores es_ES
dc.contributor.authorVílchez Rienda, José Dámasoes_ES
dc.contributor.authorSevillano Tripero, Nataliaes_ES
dc.contributor.authorEl-Azem de Haro, Nuries_ES
dc.contributor.authorRueda Cabrera, Ricardoes_ES
dc.contributor.authorSalto González, Rafael es_ES
dc.contributor.authorLópez-Pedrosa, José M.es_ES
dc.identifier.citationManzano, M.; et al. Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance. Nutrition and Metabolism, 13: 32 (2016). []es_ES
dc.description.abstractBackground: Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an apple polyphenol extract (APE) in an insulin-resistant rat model and to determine the molecular basis of insulin sensitivity action in skeletal muscle cells.en_EN
dc.description.abstractMethods: Acute effect of APE on the postprandial hyperglycemic response was assayed in 15 week old obese Zucker rats (OZR), by using a meal tolerance test (MTT). The ability of APE to improve whole peripheral insulin sensitivity was also assayed in a chronic study by using the euglycemic-hyperinsulinemic clamp technique. To elucidate the molecular mechanisms, rat L6 myotubes were used. Glucose uptake was measured by using 2-[3H]-Deoxy-Glucose (2-DG) and specific inhibitors, as well as phosphorylation status of key kinases, were used to determine the implicated signaling pathway.en_EN
dc.description.abstractResults: In vivo study showed that nutritional intervention with APE induced an increase of insulin sensitivity with an increase of glucose infusion rate (GIR) of 45 %. Additionally, in vitro results showed a synergistic effect between APE and insulin as well as increased glucose uptake through GLUT4 translocation in muscle cells. This translocation was mediated by phosphatydil inositol 3-kinase (PI3K) and peroxisome proliferator-activated receptor-gamma (PPARγ) signaling pathways.en_EN
dc.description.abstractConclusions: As a whole, this study describes the mechanisms involved in the insulin sensitizing effect of APE, which could be considered a promising ingredient for inclusion in nutritional products focused on the management of chronic diseases such as diabetes.en
dc.description.sponsorshipThis research was supported by funds from Abbott Laboratories S.A.en_EN
dc.publisherBiomed Centrales_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licenseen_EN
dc.subjectApple polyphenol extracten_EN
dc.subjectInsulin sensitivityen_EN
dc.subjectBlood glucose uptakeen_EN
dc.subjectSkeletal muscleen_EN
dc.subjectDiabetes en_EN
dc.titleApple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistanceen_EN

Ficheros en el ítem


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Excepto si se señala otra cosa, la licencia del ítem se describe como Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License