Coenzyme Q and Its Role in the Dietary Therapy against Aging
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Varela-López, A.; et al. Coenzyme Q and Its Role in the Dietary Therapy against Aging. Molecules, 21(3): 373 (2016). [http://hdl.handle.net/10481/44796]
PatrocinadorF.G. was supported by a Fondazione Umberto Veronesi Fellowship. A.V.-L. is recipient of a predoctoral FPU contract from the Spanish Ministry of Education, Culture and Sport and member of the research group CTS-627 supported by Junta de Andalucia and University of Granada.
Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule found in different dietary sources, which can be taken up and incorporated into biological membranes. It is known that mitochondria have a close relationship with the aging process. Additionally, delaying the aging process through diet has aroused the interest of scientists for many years. These observations have stimulated investigation of the anti-aging potential of CoQ and its possible use in dietary therapies to alleviate the effects of aging. In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases.