Flavonoids in Inflammatory Bowel Disease: A Review
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AutorVezza, Teresa; Rodríguez-Nogales, Alba; Algieri, Francesca; Utrilla Navarro, Pilar; Rodríguez-Cabezas, María Elena; Gálvez Peralta, Julio Juan
Inflammatory bowel diseaseFlavonoidsOxidative stressEicosanoidsBarrier functionImmunomodulatory properties
Vezza, T.; et al. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients, 8(4): 211 (2016). [10.3390/nu8040211]
PatrocinadorThis work was supported by Junta de Andalucia (P10-AGR-6826 and CTS 164) and by the Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R) with funds from the European Union.; The CIBER-EHD is funded by the Instituto de Salud Carlos III.
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects.