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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/44790

Title: Flavonoids in Inflammatory Bowel Disease: A Review
Authors: Vezza, Teresa
Rodríguez-Nogales, Alba
Algieri, Francesca
Utrilla Navarro, Pilar
Rodríguez-Cabezas, María Elena
Gálvez Peralta, Julio Juan
Issue Date: 2016
Abstract: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects.
Sponsorship: This work was supported by Junta de Andalucia (P10-AGR-6826 and CTS 164) and by the Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R) with funds from the European Union.
The CIBER-EHD is funded by the Instituto de Salud Carlos III.
Publisher: MDPI
Keywords: Inflammatory bowel disease
Flavonoids
Oxidative stress
Eicosanoids
Barrier function
Immunomodulatory properties
URI: http://hdl.handle.net/10481/44790
ISSN: 2072-6643
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Vezza, T.; et al. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients, 8(4): 211 (2016). [10.3390/nu8040211]
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