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dc.contributor.authorChamorro, Virginiaes_ES
dc.contributor.authorPandolfi, Rachelees_ES
dc.contributor.authorMoreno, Lauraes_ES
dc.contributor.authorBarreira, Biancaes_ES
dc.contributor.authorMartínez-Ramas, Andreaes_ES
dc.contributor.authorMorales-Cano, Danieles_ES
dc.contributor.authorRuiz-Cabello, Jesúses_ES
dc.contributor.authorLorente, José Ángeles_ES
dc.contributor.authorDuarte Pérez, Juan Manuel es_ES
dc.contributor.authorCogolludo, Ángeles_ES
dc.contributor.authorÁlvarez-Sala, José Luises_ES
dc.contributor.authorPérez-Vizcaíno, Franciscoes_ES
dc.date.accessioned2017-02-10T11:08:09Z
dc.date.available2017-02-10T11:08:09Z
dc.date.issued2016
dc.identifier.citationChamorro, V.; et al. Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion. Molecules, 21(12): 1739 (2016). [http://hdl.handle.net/10481/44771]es_ES
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10481/44771
dc.description.abstractBackground: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock. Methods: Rats were anesthetized (80 mg/kg ketamine plus 8 mg/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were administered during resuscitation. Results: There was a trend for increased survival 84.6% (11/13) in the treated group vs. the shock group 68.4% (13/19, p > 0.05 Kaplan–Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals. Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion.en_EN
dc.description.sponsorshipSupported by FundaciónMutuaMadrileña (AP102962012), SpanishMINECO(SAF 2011-28150; SAF2014-55399R; SAF2014-58920) and ISCIII (CP12/03304, FIS 15/1492).es_ES
dc.language.isoenges_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectSystemic arterial pressureen_EN
dc.subjectLung edemaen_EN
dc.subjectHemorrhageen_EN
dc.subjectTraumaen_EN
dc.subjectReperfusionen_EN
dc.titleEffects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusionen_EN
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/molecules21121739


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