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Title: Genetic basis of Parkinson's disease in southern Spain
Other Titles: Fundamentos genéticos de la enfermedad del parkinson en el sur de España
Authors: Bandrés Ciga, Sara
Direction: Durán Ogalla, Raquel
Vives Montero, Francisco
Collaborator: Universidad de Granada. Departamento de Fisiología
Issue Date: 2016
Submitted Date: 12-Feb-2016
Abstract: In the last decades, we have witnessed a revolution in the field of genetics of Parkinson’s disease (PD), a movement disorder caused by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The discovery of deleterious mutations and genetic risk variants in familial and sporadic PD cases respectively, has increased our knowledge about the possible molecular pathways involved on its pathogenesis. This substantial progress has helped us to better understand such devastating disease, and although the route to PD diseasemodifying drugs is still long, it will hopefully be an achievable future goal. This study aims to elucidate the genetic architecture of familial and sporadic PD in Southern Spain, assessing in detail a population that has so far been poorly studied in this context.
Sponsorship: Tesis Univ. Granada. Programa Oficial de Doctorado en: Biomedicina
FPU12-01885. Beca-Contrato del Programa de Formación de Profesorado Universitario (FPU) (2013-2017)
Project WT089698/Z/09/Z: Medical Research Council (London, UK) and Welcome Trust Strategic Award.
Project ZO1 AG000949: Intramural Research Program of the National Institute on Aging, National Institutes of Health (NIH) (part of the Department of Health and Human Services, USA).
Publisher: Universidad de Granada
Description: Premio Sociedad Andaluza de Neurología al proyecto “Polimorfismos genéticos, biomarcadores plasmáticos y estrés oxidativo en la Enfermedad de Parkinson”.
Keywords: Enfermedad de Parkinson
Patogénesis
Citogenética humana
Transformación genética
Diagnóstico
Andalucía
UDC: 616.8
(460)
(043.2)
631003
URI: http://hdl.handle.net/10481/44397
ISBN: 9788491630562
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Bandrés Ciga, S. Genetic basis of Parkinson's disease in southern Spain. Granada: Universidad de Granada, 2016. [http://hdl.handle.net/10481/44397]
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