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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/44294

Title: Biological implications of insulin resistance signalling, inflammation and extracellular matrix genes in human adipose tissue-derived mesenchymal stem cell cultures
Other Titles: Implicaciones biológicas de genes de vías de señalización en la insulina, inflamación y matríz extracelular en cultivos de células madre mesenquimales derivadas de tejido adiposo humano
Authors: Ruiz-Ojeda, Francisco Javier
Direction: Aguilera García, Concepción
Gil Hernández, Ángel
Collaborator: Universidad de Granada. Departamento de Bioquímica y Biología Molecular II
Universidad de Granada. Instituto de Nutrición y Tecnología de los Alimentos "José Mataix"
Issue Date: 2016
Submitted Date: 18-Nov-2016
Abstract: El presente trabajo fue diseñado para determinar la posible función de los genes NPR3 y CAT en el metabolismo del adipocito, además para estudiar el mecanismo específico por el cual podrían contribuir a las alteraciones metabólicas asociadas a la obesidad en adipocitos humanos diferenciados.
The research group “CTS-461-Nutritional Biochemistry. Therapeutic implications, BioNIT” focuses one of its research fields on obesity. First, the group reported some studies of the association of genetic variants with childhood obesity such as 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), neuropeptide Y (NPY) and fat mass and obesity (FTO) genes (PhD defended by Olza J. 2011) (Olza J et al. 2012). Subsequently, the research group studied the potential implications of SNPs for antioxidant defense system-related genes in the risk of obesity and metabolic syndrome features in children; a PhD thesis on that subject was defended by Rupérez AI (2014) (Rupérez et al. 2013, Rupérez et al. 2014). Additionally, the group demonstrated that VAT exhibits a differential gene expression between obese and normal-weight prepuberal children (Aguilera et al. 2015). Consequently, we obtained a grant by Junta de Andalucía (project number CTS-6770), which allowed for selecting some genes that may affect obesity and its metabolic complications such as inflammation and insulin resistance. Therefore, natriuretic peptide 3 (NPR3) and catalase (CAT) genes were selected among others to study the putative role on adipocyte metabolism and its possible association with obesity. The present work was undertaken to determine the putative function of NPR3 and CAT genes on adipocyte metabolism, as well to study the specific mechanisms which might contribute to metabolic alterations related to obesity in human differentiated adipocytes.
Sponsorship: Tesis Univ. Granada. Programa Oficial de Doctorado en: Nutrición humana
Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias (FIS). Ministerio de Salud: RD08/0072/0028 y RD12/0026/0015 “Red de Salud Materno Infantil SAMID”, Redes temáticas de investigación cooperativa RETIC.
Junta de Andalucía, Consejería de Innovación y Ciencia: P10-CTS-6770 Biological implications of insulin resistance signalling, inflammation and extracellular matrix genes human adipose tissue-derived mesenchymal stem cell cultures
Ministry of Education, Culture and Sport, Spanish Government: Francisco Javier Ruiz Ojeda is the recipient of a “Formación de Profesorado Universitario, (FPU)” stipend from 2013 to 2017 (Reference: AP2012- 02068).
Publisher: Universidad de Granada
Keywords: Obesidad
Tejido adiposo
Síndrome metabólico
Resistencia a la insulina
Células madre hematopoyéticas
Estrés oxidativo
Expresión génica
UDC: 612.3
602
611
URI: http://hdl.handle.net/10481/44294
ISBN: 9788491630340
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ruiz Ojeda, F.J. Biological implications of insulin resistance signalling, inflammation and extracellular matrix genes in human adipose tissue-derived mesenchymal stem cell cultures. Granada: Universidad de Granada, 2016. [http://hdl.handle.net/10481/44294]
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