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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/44082

Title: miRNA-146A regula la interacción entre células epiteliales intestinales, microbiota y estímulos inflamatorios
Authors: Anzola Santander, Andrea
Direction: Zarzuelo Zurita, Antonio
Martínez-Agustín, Olga
González Pérez, Raquel
Collaborator: Universidad de Granada. Departamento de Farmacología
Issue Date: 2016
Submitted Date: 8-Jul-2016
Abstract: We proposed 5 main objetives in this doctoral thesis: 1. To determine changes in miRNA expression in human intestinal epithelial cells, depending on the stage of cell differentiation and inflammation. 2. To study miR-146a expression in three animal models of colitis, that differ in the involvement of the intestinal mucosal barrier and, accordingly, in the level of contact with the intestinal microbiota. 3. To study the effect of bacterial antigens and cytokines on the expression of miR-146a using IEC lines. 4. To confirm the hypothesis that miR-146a may contribute to prevent overstimulation of the immune response. 5. To study the effect of bacterial antigens and cytokines on the expression of miR-146a using organoids from mouse small intestine.
Sponsorship: Tesis Univ. Granada. Programa Oficial de Doctorado en: Medicina Clínica y Salud Pública
Publisher: Universidad de Granada
Keywords: Intestinos
Microbiología
Sistema inmunológico
Bacterias
Inflamación (Patología)
Acido ribonucleico mensajero
Células epiteliales
UDC: 616
3205
URI: http://hdl.handle.net/10481/44082
ISBN: 9788491259909
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Anzola Santander, A. miRNA-146A regula la interacción entre células epiteliales intestinales, microbiota y estímulos inflamatorios. Granada: Universidad de Granada, 2016. [http://hdl.handle.net/10481/44082]
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