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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/43528

Title: Protein crystallization in short-peptide supramolecular hydrogels: A versatile strategy towards biotechnological composite materials
Authors: Conejero-Muriel, Mayte
Contreras-Montoya, Rafael
Álvarez de Cienfuegos Rodríguez, Luis
Gavira Gallardo, José Antonio
Issue Date: 2016
Abstract: Protein crystallization in hydrogels has been explored with the main purpose of facilitating the growth of high quality crystals while increasing their size to enhance their manipulation. New avenues are currently being built for the use of protein crystals as source materials to create sensors and drug delivery vehicles, to name just a few. In this sense, short-peptide supramolecular hydrogels may play a crucial role in integrating protein crystals within a wider range of applications. In this article, we show that protein crystallization in short-peptide supramolecular hydrogels is feasible and independent of the type of peptide that forms the hydrogel and/or the protein, although the output is not always the same. As a general trend, it is confirmed that hydrogel fibers are always incorporated within crystals so that novel composite materials for biotechnological applications with enhanced properties are produced.
Sponsorship: This research was funded by the MICINN (Spain) projects BIO2010-6800 (JAG), CTQ2012-34778 (JJDM), and “Factoría Española de Cristalización” Consolider-Ingenio 2010 (JAG & MCM), and by Junta de Andalucía (Spain) project P12-FQM- 2721 (LAC). EDRF funds JAG, LAC & JMC. JJDM thanks MICINN for a Ramon y Cajal Fellowship and MCM thanks CSIC for her JAE Fellowship
Publisher: Royal Society of Chemistry
Keywords: Crystallization
Colloids
Protein crystals
Biotechnology
Drugs
Peptides
Supramomolecular chemistry
Composite materials
URI: http://hdl.handle.net/10481/43528
ISSN: 1466-8033
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Conejero-Muriel, M.; et al. Protein crystallization in short-peptide supramolecular hydrogels: A versatile strategy towards biotechnological composite materials. CrystEngComm,17: 8072-8078 (2015). [http://hdl.handle.net/10481/43528]
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