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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/42543

Title: A Spherical Brain Mapping of MR Images for the Detection of Alzheimer's Disease
Authors: Martínez-Murcia, Francisco J.
Górriz Sáez, Juan Manuel
Ramírez Pérez de Inestrosa, Javier
Ortiz, Andrés
Issue Date: 15-Sep-2016
Abstract: Magnetic Resonance Imaging (MRI) is of fundamental importance in neuroscience, providing good contrast and resolution, as well as not being considered invasive. Despite the development of newer techniques involving radiopharmaceuticals, it is still a recommended tool in Alzheimer’s Disease (AD) neurological practice to assess neurodegeneration, and recent research suggests that it could reveal changes in the brain even before the symptomatology appears. In this paper we propose a method that performs a Spherical Brain Mapping, using different measures to project the three-dimensional MR brain images onto two-dimensional maps revealing statistical characteristics of the tissue. The resulting maps could be assessed visually, but also perform a significant feature reduction that will allow further supervised or unsupervised processing, reducing the computational load while maintaining a large amount of the original information. We have tested our methodology against a MRI database comprising 180 AD affected patients and 180 normal controls, where some of the mappings have revealed as an optimum strategy for the automatic processing and characterization of AD patterns, achieving up to a 90.9% of accuracy, as well as significantly reducing the computational load. Additionally, our maps allow the visual analysis and interpretation of the images, which can be of great help in the diagnosis of this and other types of dementia.
Sponsorship: This work was partly supported by the MICINN under the TEC2008-02113 and TEC2012-34306 projects and the Consejerıa de Econom´ıa, Innovacion, Ciencia y Empleo (Junta de Andalucıa, Spain) under the Excellence Projects P09-TIC-4530 and P11-TIC-7103, as well as the “Programa de fortalecimiento de las capacidades de I+D+I en las Universidades 2014-2015”, cofunded by the European Regional Development Fund (ERDF) under Project FC14-SAF-30
Series/Report no.: Current Alzheimer Research;13(5)
Keywords: neuroimaging
spherical coordinates
URI: http://hdl.handle.net/10481/42543
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Appears in Collections:TIC218 - Artículos

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