Universidad de Granada Digibug
 

Repositorio Institucional de la Universidad de Granada >
1.-Investigación >
Departamentos, Grupos de Investigación e Institutos >
Departamento de Bioquímica y Biología Molecular III >
DBBM3 - Artículos >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/39198

Title: Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
Authors: Conde-Muíño, Raquel
Cuadros Celorrio, Marta
Zambudio, Natalia
Segura-Jiménez, Inmaculada
Cano Gutiérrez, Carlos
Palma Carazo, Pablo
Issue Date: 2015
Abstract: There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile’s ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice.
Publisher: Hindawi Publishing Corporation
Keywords: Biomarkers
Chemoradiation
Rectal Cancer
URI: http://hdl.handle.net/10481/39198
ISSN: 2314-6133
2314-6141
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Conde-Muíño, R.; et al. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International, 2015: 921435 (2015). [http://hdl.handle.net/10481/39198]
Appears in Collections:DBBM3 - Artículos

Files in This Item:

File Description SizeFormat
CondeMuino_BiomarkersChemoradiation.pdf1.28 MBAdobe PDFView/Open
Recommend this item

This item is licensed under a Creative Commons License
Creative Commons

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! OpenAire compliant DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback

© Universidad de Granada