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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/39198

Title: Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
Authors: Conde-Muíño, Raquel
Cuadros Celorrio, Marta
Zambudio, Natalia
Segura-Jiménez, Inmaculada
Cano Gutiérrez, Carlos
Palma Carazo, Pablo
Issue Date: 2015
Abstract: There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile’s ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice.
Publisher: Hindawi Publishing Corporation
Keywords: Biomarkers
Rectal Cancer
URI: http://hdl.handle.net/10481/39198
ISSN: 2314-6133
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Conde-Muíño, R.; et al. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International, 2015: 921435 (2015). [http://hdl.handle.net/10481/39198]
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