Bone Regeneration from PLGA Micro-Nanoparticles
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AuthorOrtega-Oller, Inmaculada; Padial-Molina, Miguel; Galindo-Moreno, Pablo; O'Valle, Francisco; Jódar-Reyes, Ana Belén; Peula-García, José Manuel
Hindawi Publishing Corporation
Bone regenerationPoly-lactic-co-glycolic (PLGA)Synthetic polymersBiomolecules
Ortega-Oller, I.; et al. Bone Regeneration from PLGA Micro-Nanoparticles. BioMed Research International, 2015: 415289 (2015). [http://hdl.handle.net/10481/39135]
SponsorshipThe authors wish to express their appreciation for the financial support granted by the “Ministerio de Educación y Ciencia” (MEC, Spain), Projects MAT2013-43922-R, and Research Groups no. FQM-115, no. CTS-138, and no. CTS-583 (Junta de Andalucía, Spain). Partial support was also provided by the Andalucía Talent Hub Program from the Andalusian Knowledge Agency, cofunded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND, Grant Agreement no. 291780) and the Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía (Miguel Padial-Molina).
Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed.