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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/37696

Title: Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota
Authors: Cian, Raúl E.
Drago, Silvina R.
Sánchez de Medina, Fermín
Martínez-Augustín, Olga
Issue Date: 2015
Abstract: Based on their composition, marine algae, and namely red seaweeds, are good potential functional foods. Intestinal mucosal barrier function refers to the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules. Here, we will first outline the component of seaweeds and will summarize the effects of these on the regulation of mucosal barrier function. Special attention will be paid to unique components of red seaweeds: proteins and derived peptides (e.g., phycobiliproteins, glycoproteins that contain “cellulose binding domains”, phycolectins and the related mycosporine-like amino acids) together with polysaccharides (e.g., floridean starch and sulfated galactans, such as carrageenans, agarans and “dl-hybrid”) and minerals. These compounds have been shown to exert prebiotic effects, to regulate intestinal epithelial cell, macrophage and lymphocyte proliferation and differentiation and to modulate the immune response. Molecular mechanisms of action of peptides and polysaccharides are starting to be elucidated, and evidence indicating the involvement of epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFR), Toll-like receptors (TLR) and signal transduction pathways mediated by protein kinase B (PKB or AKT), nuclear factor-κB (NF-κB) and mitogen activated protein kinases (MAPK) will also be summarized. The need for further research is clear, but in vivo experiments point to an overall antiinflammatory effect of these algae, indicating that they can reinforce membrane barrier function.
Sponsorship: This work was funded by the Ministerio de Economía y Competividad (SAF2011-22922, SAF2011-22812, BFU2014-57736-P and AGL201E-58883-R) and by Junta de Andalucía (CTS164, CTS235 and CTS6736) of the Spanish Government, and by a grant from the Argentinian Government (CAI + D 2011 PI 0292 LI). CIBERehd is funded by the Instituto de Salud Carlos III (Spain).
Publisher: MDPI
Keywords: Red seaveeds
Sulfated galactans
Bioactive peptides
Rhodophyta
Mucosal barrier function
Immunomodulation
Cell differentiation
Cell proliferation
NF-κB
MAPK
URI: http://hdl.handle.net/10481/37696
ISSN: 1660-3397
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Cian, R.E.; et al. Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota. Marine Drugs, 13(8): 5358-5383 (2015). []
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