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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/37665

Title: Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials
Authors: López-López, Modesto T.
Scionti, Giuseppe
Oliveira, Ana C.
García López-Durán, Juan de Dios
Campos, Antonio
Alaminos Mingorance, Miguel
Rodríguez, Ismael Ángel
Issue Date: 24-Jul-2015
Abstract: We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces. This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
Sponsorship: This work was supported by FIS2013-41821-R (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (co-funded by FEDER funds, EU) to MTLL, GS, JDGD and IAR; FIS PI14/0955 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III-co-funded by FEDER funds, EU) to AC and MA; FIS PI14/1343 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III -co-funded by FEDER funds, EU) to AC and MA; PI11/01582 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III -co-funded by FEDER funds, EU) to AC and MA; and P10-CTS-6060 (http://www.juntadeandalucia.es/organismo​s/economiainnovacioncienciayempleo.html) Junta de Andalucía, Spain (Consejería de Innovación, Ciencia y Empleo—Proyectos de Excelencia) to AC and MA.
Publisher: Public Library of Science (PLOS)
Keywords: Magnetic field-responsive
Biomaterials
Nanoparticles
Mechanical properties
Deformation
Polymers
Tissue mechanics
Fibrin
URI: http://hdl.handle.net/10481/37665
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: López-López, M.T.; et al. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. Plos One, 10(7): e0133878 (2015). [http://hdl.handle.net/10481/37665]
Appears in Collections:FQM144 - Artículos

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