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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/36629

Title: Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit
Authors: Mapelli, Lisa
Pagani, Martina
Garrido Alcázar, Jesús
D'Angelo, Egidio
Issue Date: 2015
Abstract: The way long-term potentiation (LTP) and depression (LTD) are integrated within the different synapses of brain neuronal circuits is poorly understood. In order to progress beyond the identification of specific molecular mechanisms, a system in which multiple forms of plasticity can be correlated with large-scale neural processing is required. In this paper we take as an example the cerebellar network, in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses. Cerebellar LTP and LTD occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei) and correspondingly regulate the function of their three main neurons: granule cells (GrCs), Purkinje cells (PCs) and deep cerebellar nuclear (DCN) cells. All these neurons, in addition to be excited, are reached by feed-forward and feed-back inhibitory connections, in which LTP and LTD may either operate synergistically or homeostatically in order to control information flow through the circuit. Although the investigation of individual synaptic plasticities in vitro is essential to prove their existence and mechanisms, it is insufficient to generate a coherent view of their impact on network functioning in vivo. Recent computational models and cell-specific genetic mutations in mice are shedding light on how plasticity at multiple excitatory and inhibitory synapses might regulate neuronal activities in the cerebellar circuit and contribute to learning and memory and behavioral control.
Sponsorship: This work was supported by European Union grants to ED [CEREBNETFP7-ITN238686, REAL NET FP7-ICT270434, Human Brain Project(HBP-604102)] and by Centro Fermi grant [13(14)] to LM.
Publisher: Frontiers Foundation
Keywords: Cerebellum
Inhibitory synapse
Excitatory synapse
LTP (Long-term potentiation)
LTD (Long-term depression)
URI: http://hdl.handle.net/10481/36629
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Mapelli, L.; et al. Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit. Frontiers in Cellular Neuroscience, 9: 169 (2015). [http://hdl.handle.net/10481/36629]
Appears in Collections:OpenAIRE (Open Access Infrastructure for Research in Europe)
DATC - Artículos

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