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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/35709

Title: Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study
Authors: Gutiérrez-Fernández, José
Luna del Castillo, Juan de Dios
Mañanes-González, Sara
Carrillo-Ávila, José Antonio
Gutiérrez, Blanca
Cervilla, Jorge A.
Sorlózano Puerto, Antonio
Issue Date: 2015
Abstract: In the present study we have performed both a meta-analysis and an analytical study exploring the presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii antibodies in a sample of 143 schizophrenic patients and 143 control subjects. The meta-analysis was performed on papers published up to April 2014. The presence of serum immunoglobulin G and immunoglobulin A was performed by enzyme-linked immunosorbent assay test. The detection of microbial DNA in total peripheral blood was performed by nested polymerase chain reaction. The meta-analysis showed that: 1) C. pneumoniae DNA in blood and brain are more common in schizophrenic patients; 2) there is association with parasitism by T. gondii, despite the existence of publication bias; and 3) herpes viruses were not more common in schizophrenic patients. In our sample only anti-Toxoplasma immunoglobulin G was more prevalent and may be a risk factor related to schizophrenia, with potential value for prevention.
Sponsorship: Part of this work was presented at the Royal Academy of Medicine of Spain.
Publisher: Dove Press
Keywords: Meta-analysis
Analytical study
Chlamydia pneumoniae
Herpes simplex virus type 1
Human herpes virus 6
Toxoplasma gondii
Schizophrenia
URI: http://hdl.handle.net/10481/35709
ISSN: 1178-2021
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Gutiérrez-Fernández, J.; et al. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study. Neuropsychiatric Disease and Treatment, 11: 843-852 (2015). [http://hdl.handle.net/10481/35709]
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