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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/35708

Title: TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy
Authors: Canhão, Helena
Rodrigues, Ana Maria
Santos, María José
Carmona-Fernandes, Diana
Bettencourt, Bruno F.
Cui, Jing
Rocha, Fabiana L.
Canas Silva, José
Polido-Pereira, Joaquim
Pereira Silva, José Alberto
Costa, José Antonio
Araujo, Domingos
Silva, Cândida
Santos, Helena
Duarte, Cátia
Cáliz, Rafael
Filipescu, Ileana
Pimentel-Santos, Fernando
Branco, Jaime
Sainz, Juan
Plenge, Robert M.
Solomon, Daniel H.
Bruges-Armas, Jácome
Da Silva, José Antonio P.
Eurico Fonseca, João
Karlson, Elizabeth W.
Issue Date: 2015
Abstract: Background. The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. Methods. We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients. Results. No association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in TRAF1/C5 region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis. Conclusion. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response.
Sponsorship: This work was supported by a grant from Harvard-Portugal Program HMSP-ICS/SAU-ICT/0002/2010. Daniel H. Solomon received support for this work from the NIH (K24-AR-055989). Elizabeth W. Karlson received support for this work from NIH (K24-AR-AR0524). Reuma.pt received unrestricted grants from Abbott, Bristol-Myers Squibb, Merck Sharp and Dohme, Pfizer, Roche, and UCB Pharma.
Publisher: Hindawi Publishing Corporation
Keywords: Rheumatoid arthritis
Anti-tumor necrosis factor (anti-TNF)
Southern European
PTPRC locus
URI: http://hdl.handle.net/10481/35708
ISSN: 2314-6133
2314-6141
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Canhão, H.; et al. TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy. BioMed Research International, 2015: 490295 (2015). [http://hdl.handle.net/10481/35708]
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