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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/34863

Title: Preparation of multi-functionalized Fe3O4/Au nanoparticles for medical purposes
Authors: Ramos-Tejada, María del Mar
Viota, Julián L.
Rudzka, Katarzyna
Delgado, Ángel V.
Issue Date: 2015
Abstract: In this work, we investigate a route towards the synthesis of multi-functionalized nanoparticles for medical purposes. The aim is to produce magnetite/gold (Fe3O4/Au) nanoparticles combining several complementary properties, specifically, being able to carry simultaneously an antitumor drug and a selected antibody chosen so as to improve specificity of the drug vehicle. The procedure included, firstly, the preparation of Fe3O4 cores coated with Au nanoparticles: this was achieved by using initially the layer-by-layer technique in order to coat the magnetite particles with a three polyelectrolyte (cationic-anionic-cationic) layer. With this, the particles became a good substrate for the growth of the gold layer in a well-defined core–shell structure. The resulting nanoparticles benefit from the magnetic properties of the magnetite and the robust chemistry and the biostability of gold surfaces. Subsequently, the Fe3O4/Au nanoparticles were functionalized with a humanized monoclonal antibody, bevacizumab, and a chemotherapy drug, doxorubicin. Taken together, bevacizumab enhances the therapeutic effect of chemotherapy agents on some kinds of tumors. In this work we first discuss the morphology of the particles and the electrical characteristics in the successive synthesis stages. Special attention is paid to the chemical stability of the final coating, and the physical stability of the suspensions of the nanoparticles in aqueous solutions and phosphate buffer. We describe how optical absorbance and electrokinetic data provide a follow up of the progress of the nanostructure formation. Additionally, the same techniques optical absorbance and electrokinetic measurements are employed to demonstrate that the composite nanoparticles are capable of loading/releasing doxorubicin and/or bevacizumab.
Sponsorship: Financial support from Junta de Andalucía (PE2012-FQM0694), and Ministerio de Economía y Competitividad (FIS2013-47666/C3-1-R), Spain.
Publisher: Elsevier
Description: The edited version of this paper can be accessed in the following address: http://dx.doi.org/10.1016/j.colsurfb.2015.02.002
Keywords: Bevacizumab
Doxorubicin
Drug loading
Drug release
Magnetite/gold nanoparticles
Monoclonal antibody
URI: http://hdl.handle.net/10481/34863
ISSN: 0927-7765
1873-4367
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ramos Tejada, M.M.; et al. Preparation of multi-functionalized Fe3O4/Au nanoparticles for medical purposes. Colloids and Surfaces B: Biointerfaces, (2015). [http://hdl.handle.net/10481/34863]
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