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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/34557

Title: Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up
Authors: Arrebola Moreno, Juan Pedro
Fernández, Mariana F.
Martín-Olmedo, Piedad
Molina-Molina, José-Manuel
Sánchez-Pérez, María J.
Sánchez-Cantalejo Ramírez, Emilio
Molina-Portillo, Elena
Expósito Hernández, José
Bonde, Jens Peter
Olea, Nicolás
Issue Date: 2014
Abstract: There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01–1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.
Sponsorship: This study was supported in part by research grants from the Spanish Ministry of Health (FIS 02/974, EUS2008-03574), CIBER de Epidemiología; Junta de Andalucía (01/264, P09-CTS-5488 Project of Excellence, PI-0675-2010, and PI-0513-2012), and the Instituto de Salud Carlos III (FIS PI11/0610).
Publisher: Elsevier
Keywords: Persistent organic pollutants
Adipose tissue
Cancer
Prospective study
Hazard ratio
Follow-up
URI: http://hdl.handle.net/10481/34557
ISSN: 0048-9697
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Arrebola, J.P.; et al. Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up [pre-print]. Science of the Total Environment, 500-501: 243-249 (2014). [http://hdl.handle.net/10481/34557]
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