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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/33677

Title: Methylphenidate Ameliorates Depressive Comorbidity in ADHD Children without any Modification on Differences in Serum Melatonin Concentration between ADHD Subtypes
Authors: Cubero-Millán, Isabel
Molina-Carballo, Antonio
Machado-Casas, Irene
Fernández-López, Luisa
Martínez-Serrano, Sylvia
Tortosa-Pinto, Pilar
Ruiz-López, Aida
Luna del Castillo, Juan de Dios
Uberos, José
Muñoz-Hoyos, Antonio
Issue Date: 2014
Abstract: The vast majority of Attention-deficit/hyperactivity disorder (ADHD) patients have other associated pathologies, with depressive symptoms as one of the most prevalent. Among the mediators that may participate in ADHD, melatonin is thought to regulate circadian rhythms, neurological function and stress response. To determine (1) the serum baseline daily variations and nocturnal excretion of melatonin in ADHD subtypes and (2) the effect of chronic administration of methylphenidate, as well as the effects on symptomatology, 136 children with ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR criteria) were divided into subgroups using the “Children’s Depression Inventory” (CDI). Blood samples were drawn at 20:00 and 09:00 h, and urine was collected between 21:00 and 09:00 h, at inclusion and after 4.61 ± 2.29 months of treatment. Melatonin and its urine metabolite were measured by radioimmunoassay RIA. Factorial analysis was performed using STATA 12.0. Melatonin was higher predominantly in hyperactive-impulsive/conduct disordered children (PHI/CD) of the ADHD subtype, without the influence of comorbid depressive symptoms. Methylphenidate ameliorated this comorbidity without induction of any changes in the serum melatonin profile, but treatment with it was associated with a decrease in 6-s-melatonin excretion in both ADHD subtypes. Conclusions: In untreated children, partial homeostatic restoration of disrupted neuroendocrine equilibrium most likely led to an increased serum melatonin in PHI/CD children. A differential cerebral melatonin metabolization after methylphenidate may underlie some of the clinical benefit.
Sponsorship: Funding for this study was provided by the Health Research Fund (Fondo de Investigaciones sanitarias (FIS); Spanish Ministry of Science and Innovation), FIS-PI07-0603.
Publisher: MDPI
Keywords: Children
ADHD
ADHD subtypes
Comorbidities
Depressive symptoms
CDI
Prolonged release methylphenidate
Melatonin
6-sulphatoxy-melatonin
URI: http://hdl.handle.net/10481/33677
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Cubero-Millán, I.; et al. Methylphenidate Ameliorates Depressive Comorbidity in ADHD Children without any Modification on Differences in Serum Melatonin Concentration between ADHD Subtypes. International Journal of Molecular Sciences, 15(9): 17115-17129 (2014). [http://hdl.handle.net/10481/33677]
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