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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/32706

Title: The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans
Authors: Olivares Martín, Mónica
Díaz-Ropero, María Paz
Gómez, Nuria
Lara-Villoslada, Federico
Sierra Ávila, Saleta
Maldonado Jurado, Juan Antonio
Martín, Rocío
Rodríguez, Juan M.
Xaus Pey, Jordi
Issue Date: 2006
Abstract: Orally ingested probiotic bacteria are able to modulate the immune system. However, differences exist in the immunomodulatory effects of different probiotic strains. Moreover, different regulatory effects, which depend on the health status of the consumer, have been identified. This work describes a randomized, doubleblind, placebo-controlled human clinical trial to investigate the immune effects on healthy people of a fermented product containing two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, which was compared with another fermented product, a standard yogurt. Consumption of either the new product or yogurt increased the proportion of phagocytic cells, including monocytes and neutrophils, as well as their phagocytic activity. However, combination of the product containing the strains L. gasseri CECT 5714 and L. coryniformis CECT 5711 also induced an increase in the proportion of natural killer (NK) cells and in IgA concentrations. The effects were higher after two weeks of treatment than after 4 weeks, which suggests regulation of the immune system. In addition, the new product enhanced immunity in the participants to a greater extent than did the control standard yogurt.
Sponsorship: This work was supported by Puleva Biotech SA. Federico Lara-Villoslada and Saleta Sierra are recipients of a fellowship from the Fundación Universidad-Empresa, Universidad de Granada, Spain. Rocío Martín is recipient of a grant from the Comunidad de Madrid, Spain.
Publisher: Sociedad Española de Microbiología
Keywords: Lactobacillus gasseri
Lactobacillus coryniformis
Probiotics
Human clinical trial
Immune response
URI: http://hdl.handle.net/10481/32706
ISSN: 1139-6709
Citation: Olivares, M.; et al. The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans. International Microbiology, 9(1): 47-52 (2006). [http://hdl.handle.net/10481/32706]
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