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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/32637

Title: Toscana Virus in Spain
Authors: Sanbonmatsu-Gámez, Sara
Pérez-Ruiz, Mercedes
Collao, Ximena
Sánchez-Seco, María Paz
Morillas-Márquez, Francisco
Rosa-Fraile, Manuel de la
Navarro-Marí, José María
Tenorio, Antonio
Issue Date: 2005
Abstract: Toscana virus (TOSV, Phlebovirus, family Bunyaviridae) infection is one of the most prevalent arboviruses in Spain. Within the objectives of a multidisciplinary network, a study on the epidemiology of TOSV was conducted in Granada, in southern Spain. The overall seroprevalence rate was 24.9%, significantly increasing with age. TOSV was detected in 3 of 103 sandfly pools by viral culture or reverse transcription–polymerase chain reaction from a region of the L gene. Nucleotide sequence homology was 99%–100% in TOSV from vectors and patients and 80%–81% compared to the Italian strain ISS Phl.3. Sequencing of the N gene of TOSV isolates from patients and vectors indicated 87%–88% and 100% homology at the nucleotide and amino acid levels, respectively, compared to the Italian strain. These findings demonstrate the circulation of at least 2 different lineages of TOSV in the Mediterranean basin, the Italian lineage and the Spanish lineage.
Sponsorship: Grant sponsor was Red EVITAR, Fondo de Investigaciones Sanitarias, Spanish Ministry of Health, grant no. G03/059. Ximena Collao has a research grant from Valparaiso University (MECESUP project, Chile). The study of vectors, i.e., capture of phlebotomines and taxonomic classification, was supported by the Junta de Andalucía, research grant CVI 176. Dr Sanbonmatsu-Gámez is a microbiologist on a fellowship from the EVITAR network (Fondo de Investigaciones Sanitarias, Spanish Ministry of Health; grant no. G03/059). Her research interest focuses on viral infectious diseases, especially arthropodborne viral diseases.
Publisher: U.S. Department of Health and Human Services. Centers for Disease Control and Prevention
Keywords: Toscana virus
Seroprevalence
Phylogeny
Vectors
Spain
Research
URI: http://hdl.handle.net/10481/32637
ISSN: 1080-6040
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Sanbonmatsu-Gámez, S.; et al. Toscana Virus in Spain. Emerging Infectious Diseases, 11(11): 1701-1707 (2005). [http://hdl.handle.net/10481/32637]
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